How to induce an effective immune response against HIV ? The lessons of HIV-2

Nicolas Manel has shown that the ability of HIV2 to express the Vpx protein inhibits the HIV restriction factor SAMHD1, which inhibits reverse transcriptase by deprivation of the deoxynucleotides required for DNA synthesis in dendritic cells, thereby amplifying the T immune response to HIV Ag present in dendritic cells. Conversely, HIV1, which lacks a Vpx element in its genome, can persist "hidden" within dendritic cells, contributing to the persistence of the reservoir.