Anti-infectious immunity (2)

This year, we continued the exploration begun last year of the determinants of anti-infectious immunity in a number of microbial pathologies: infection by the human immunodeficiency virus (HIV), infection by intracellular microorganisms including tuberculosis, infection by cytomegalovirus (CMV) and in the particular context of infections of the nervous system. We have sought to highlight the diversity of immune responses at play by analyzing experimental models and human genetic pathologies, as well as the escape strategies developed by microorganisms over the course of evolution. Wherever possible, the analysis of current knowledge has served as a basis for reflection on the possibilities of therapeutic and preventive interventions (vaccination) currently under experimental or clinical evaluation.