Abstract
Different mechanisms leading to enhancersmoving closer to their target genes. CTCF dependence and non-dependence. Pathologies induced by causes involving enhancers (enhanceropathies) and the function of transposable elements in the evolution of gene regulation.
In this sixth and final lesson, different mechanisms for bringing regulatory sequences closer to their target genes are discussed. While some of these mechanisms depend on the presence of CTCFs, others are independent of them.
The discussion then turns to enhanceropathies, i.e. pathologies deriving from problems linked to regulatory sequences and not to the genes themselves. Examples are shown that illustrate different categories of such pathologies, from the pure and simple absence of an enhancer to complex rearrangements of the genome that affect the contacts between enhancers and promoters. The lecture concludes with a brief overview of the critical importance of transposable elements in regulatory evolution.
