Murielle Lombard

After completing a thesis in biochemistry at Grenoble's Joseph Fourier University in 2001, on a new enzymatic system for combating oxidative stress, Murielle Lombard completed a post-doctorate at the University of Utah in Salt Lake City in Sheila David's laboratory, studying DNA repair enzymes. Recruited as a CNRS researcher at Paris Descartes in 2004, she developed a theme centered on the use of cytochromes P450 for biocatalysis and studied a human orphan cytochrome P450. At the Collège de France since 2012, she is interested in the biosynthetic pathway of Ubiquinone, a redox membrane lipid that acts as an electron carrier in the respiratory chain, as well as an antioxidant. In this context, she is studying the Ubi proteins of the Ubiquinone biosynthesis pathway at biochemical, structural and mechanistic levels, using a combination of molecular genetics, site-directed mutagenesis, biochemistry, molecular biophysics (fast kinetics) and structural biology (X-ray crystallography). She has identified a mega multi-protein complex of seven Ubi proteins, and is now focusing on a novel oxygen-dependent anaerobic hydroxylation enzyme system.