Research paths : Noémie Brassard-Jollive

Tumor vascularization in kidney cancer! This is the research focus of Noémie Brassard-Jollive, a doctoral student at the Collège de France.

Follow his webinar " Vascularized spheroids: laboratory mini-tumors that advance cancerology"! This event, organized by the ChADoC association (Chercheurs Associés et Doctorants du Collège de France), will be held on December¹, 2021, from 6:00 pm to 6:45 pm, via Zoom.

Webinar presentation

"Vascularized spheroids: laboratory mini-tumors that advance oncology "

Cancer is caused by the anarchic multiplication of tumor cells. To grow, the tumor needs nutrients and oxygen. This is why it secretes molecules that promote the growth of blood capillaries, a process known as angiogenesis. Anti-angiogenic treatments, which alter the formation of these capillaries, are a therapeutic strategy for beating cancer, and kidney cancer in particular. However, this strategy is limited by the development of resistance. Today, there is a crucial lack of relevant models to study these resistance mechanisms and discover new anti-cancer molecules. This is why we have developed a model outside the living organism, in three dimensions, called a vascularized spheroid. Using this innovative approach, we have mimicked the aberrant vascularization of kidney cancer for the first time, and are proposing this model as a relevant tool for preclinical research into new therapeutic molecules.