Abstract
In 1994, BRCA1, the emblematic breast cancer predisposition gene, was identified thanks to the contribution of families with multiple cases. Thirty years later, with a dozen other genes identified and tens of thousands of tests carried out worldwide thanks to the advent of ultra-high-throughput sequencing, tumor locations have been pinpointed and risks quantified. From a genetic trait obeying a dominant Mendelian model, we have moved on to a multifactorial disease. Efforts to identify risk-modifying factors, both genetic and non-genetic, will make it possible to determine individual risks and adapt management.
