Abstract
This lecture will address a major question in human genomics and public health : how do genetics and the environment interact in the development of disease ? We'll start by examining how the environment - theexposome - can affect our health, then look at gene-environment (GxE) interactions and methodologies for detecting them. The importance of large biobanks in analyzing these interactions will be highlighted through examples of clinical conditions resulting from the interaction between a genetic predisposition and the environment, such as obesity. Finally, the lecture will cover the molecular mechanisms involved in gene-environment interactions, such as gene regulation and epigenetic modifications influenced by the environment.
