Presentation

Born November 12 1936, Frankfurt/Main, Germany.

Education

  • 1956-1962 : Studied medicine and chemistry in Frankfurt/Main and Munich
  • 1959-1961 : Medical thesis at the Institute of Chemistry, University of Frankfurt/Main
  • 1962 : Doctorate in medicine, Master's degree in chemistry

Professional career

  • 1962-1963 : Postdoctoral training at the Institut Pasteur, Paris, in the laboratory of P. Grabar
  • 1964-1966 : Assistant Professor at the Institute of Genetics, University of Cologne
  • Since 1966 : Head of the Immunology Department at the Institute of Genetics, University of Cologne
  • 1969 : EMBO Senior Fellow at the National Institute of Medical Research, London, in the laboratory of N.A. Mitchison
  • 1970 : Professor of Molecular Genetics at the Institute of Genetics, University of Cologne
  • 1970 : Member of the Executive Board of the Institute of Genetics
  • 1995-1996 : Visiting Professor at the Collège de France, holding the annual European Chair
  • 1996 : Part-time member of the European Molecular Biology Laboratory (EMBL)
  • 1996 : Coordinator of the mouse genetics program at Monterotondo, Italy

Chair

Selected bibliography

Main publications

  • The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bone marrow

    Förster I. et Rajewsky K., « The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bone marrow », Proc. Natl. Acad. Sci. USA, n° 87, 1990, p. 4781-4784.

  • Maintenance of B cell memory by long-lived cells generated from proliferating precursors

    Schittek B. et Rajewsky K., « Maintenance of B cell memory by long-lived cells generated from proliferating precursors », Nature, n° 346, 1990, p. 749-751.

  • Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly 1 B cell and B-CLL progenitor generation

    Gu H., I. Förster I. et Rajewsky K., « Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly 1 B cell and B-CLL progenitor generation », EMBO J., n° 9, 1990, p. 2133-2140.

  • Analysis of the B cell progenitor compartment at the level of single cells

    Ehlich A., Martin V., Müller W. et Rajewsky K., « Analysis of the B cell progenitor compartment at the level of single cells », Curr. Biol., n° 4, 1994, p. 573-583.

  • Interclonal generation of antibody mutants in germinal centers

    Jacob J., Kelsoe G., Rajewsky K. et Weiss U., « Interclonal generation of antibody mutants in germinal centers », Nature, n° 354, 1991, p. 389-392.

  • Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections

    Küppers R., Zhao M., Hansmann M.-L. et Rajewsky K., « Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections », EMBO J., n° 12, 1993, p. 4955-4967.

  • Burkitt's lymphoma is a malignancy of nature B cells expressing somatically mutated V region genes

    Klein U., Klein G., Ehlin-Henriksson B., K. Rajewsky K. et Küppers R., « Burkitt's lymphoma is a malignancy of nature B cells expressing somatically mutated V region genes », Mol. Med., n° 1, 1995, p. 495-505.

  • Hodgkin's disease : Hodgkin and Reed-Sternberg cells picked from histological sections show clonal Ig gene rearrangements and appear to be derived from B cells at various stages of development

    Küppers R., Rajewsky K., Zhao M., Simons G., Laumann R., Fischer R. et Hansmann M.-L., « Hodgkin's disease : Hodgkin and Reed-Sternberg cells picked from histological sections show clonal Ig gene rearrangements and appear to be derived from B cells at various stages of development », Proc. Nat. Acad., USA, n° 91, 1994, p. 10962-10966.

  • Interleukin-10 deficient mice develop chronic entercolitis

    Kühn R., Löhler J., Rennick D., Rajewsky K. et Müller W., « Interleukin-10 deficient mice develop chronic entercolitis », Cell, n° 75, 1993, p. 263-274.

  • A B cell deficient mouse generated through targeted disruption of the membrane exon of the immunoglobulin m chain

    Kitamura D., Roes J., Kühn R. et Rajewsky K., « A B cell deficient mouse generated through targeted disruption of the membrane exon of the immunoglobulin m chain », Nature, n° 350, 1991, p. 423-426.

  • A critical role of 15 protein in B cell development

    Kitamura D., Kudo A., Schaal S., Müller W., Melchers F. et Rajewsky K., « A critical role of 15 protein in B cell development », Cell, n° 69, 1992, p. 823-831.

  • Deletion of the immunoglobulin K chain intron enhancer abolishes K chain gene rearrangement in cis but not chain gene rearrangement in trans

    Takeda S., Zou Y., Bluethmann H., Kitamura D., Müller U. et Rajewsky K., « Deletion of the immunoglobulin K chain intron enhancer abolishes K chain gene rearrangement in cis but not chain gene rearrangement in trans », EMBO J., n° 12, 1993, p. 2329-2336.

  • Impairment of T cell-dependant B-cell responses and B-1 cell development in CD19-deficient mice

    Rickert R.C., Rajewsky K. et Roes J., « Impairment of T cell-dependant B-cell responses and B-1 cell development in CD19-deficient mice », Nature, n° 376, 1995, p. 352-355.

  • Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

    Taki S., Meiering M. et Rajewsky K., « Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus », Science, n° 262, 1993, p. 1268-1271.

  • ​ Cre-lox P- mediated gene replacement : a mouse strain producing humanized lgG1 antibodies ​

    Y. Zou, Müller W., Gu H. et Rajewsky K., « Cre-lox P- mediated gene replacement : a mouse strain producing humanized lgG1 antibodies », Curr. Biol., n° 4, 1994, p. 1099-1103.

  • Deletion of a DNA polymerase B gene segment in T cells using cell type-specific gene targeting

    Gu H., Marth J. D., Orban P. C., Mossmann H. et Rajewsky K., « Deletion of a DNA polymerase B gene segment in T cells using cell type-specific gene targeting », Science, n° 265, 1994, p. 103-106.

  • Inducible gene targeting in mice

    Kühn R., Schwenk F., Aguet M et Rajewsky K., « Inducible gene targeting in mice », Science, n° 269, 1995, p. 1427-1429.