The Collège de France congratulates Prof. Jean-Louis Mandel, winner of the Kavli 2022 prize. Eleven researchers were honored this year. Prof. Jean-Louis Mandel, the only Frenchman on the list of recipients, receives the award in the neuroscience category for his work on Fragile X syndrome, the most common cause of familial mental retardation. Honorary Professor at the Collège de France, he held the Human Genetics Chair from 2003 to 2016.