After two years of evolution, the Covid-19 pandemic continues its global progression. Waves, now supported by the appearance of SARS-CoV-2 genotypic variants, follow one another. The increase in the virus's transmissibility, without any exacerbation of its virulence, seems to mark the profile of human-virus co-evolution and map out the pandemic's future "roadmap"... This adaptation will condition the pandemic's eventual "exit".
"Exit" is a euphemism that poorly conceals our ignorance of what a "halt" to the Covid-19 pandemic might look like. Will it stop?
What role will human intervention, particularly vaccination, have played in its evolution? How much of the unknown is left by the extraordinary scientific progress in what Charles Nicolle called the "genius" of infectious diseases? Will we have to "learn to live" with SARS-CoV-2?
What can we learn from the history of major pandemics about all these issues, which have far-reaching health, economic, social, psychological and even geostrategic consequences?
Does it enable us to define a rational framework, an epistemology of pandemic finitude?
