What lectures can be drawn from the pinball game conducted on the cancer methylome ?

Abstract

The discovery of numerous and frequent mutations in epigenome modifiers have highlighted the importance of epigenetic mechanisms in cancer. In addition, epimutations such as aberrant DNA met hylation have been reported to constitute the most frequent changes in many cancers. To gain insights into the underlying mechanisms and potential therapeutic targets, we have analysed a range of cancer methylomes in the context of additional perturbations such as specifie mutations, viral infection and reprogramming.

References

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