Abstract of the presentation by Fouzia Boulmedais
Nanocoatings of polysaccharides and proteins with bioactive properties for biomaterials
Biomaterials are medical devices designed to diagnose, treat or prevent disease. Their surface is where interactions with the biological environment mainly take place. By controlling these interactions, it is possible to improve their biocompatibility and confer bioactive properties. This is achieved by applying a coating to the surface of biomaterials. Simple to implement, the layer-by-layer technique enables nanometric films to be deposited on all types of surface, offering great potential. Generally ranging in thickness from 10 nm to 1 µm, these films are obtained at room temperature by alternate adsorption of oppositely charged polymers. The properties of these multilayer films can be adjusted according to the physico-chemical conditions under which they are produced (type of polymer, pH, ionic strength, etc.), enabling the immobilization of bioactive (macro)molecules (proteins, peptides, polyphenols, etc.). Drawing on nature's ingenuity, the work presented will describe how to endow surfaces with antibacterial properties or capable of inducing cell differentiation using polysaccharides and proteins. At the interface of chemistry and biology, this work was carried out in collaboration with Lydie Ploux (Inserm U1121, Strasbourg) and Halima Kerdjoudj (BIOS EA 4671, Reims).
