Abstract
The first draft of the genome provided the roadmap for the last fifteen years of human genetics research. The era of Big Data, combined with a very substantial reduction in the cost of sequencing, has encouraged the establishment of global platforms for interrogating population variation worldwide. In just a few years, tens of thousands of complete genome sequences have been made available for humans and extinct hominids, as well as for thousands of other species.
For population genetics, these advances have opened up a previously unimaginable opportunity to reconstruct the genealogical and mutational history of man and other species, and pushed back the limits of what we can deduce about the evolutionary and genetic forces that have affected each region of the genome.
