Nuclear receptors and oncogenesis

Regulation of gene expression is an essential aspect of cancer transformation. Following on from last year's lectures on a key regulator of cellular stress (P53), this year's lectures focused on the historical case of nuclear receptors. Gene transcription is subject to multiple regulations, some of the main principles of which were recalled, with emphasis on those most relevant to this particular class of transcriptional activators. Anti-hormone therapy is probably one of the most effective anti-cancer treatments. New mechanistic elements have emerged in recent years, justifying this lecture.