Salmonella : from diarrhea to typhoid fever

Salmonella has numerous interactions with various host tissues and cells, as well as with the intestinal microbiota, during the infectious process. Typhoid fever has been described in detail, but models producing gastroenteritis in mice have only recently been developed. Using these models, we have studied various aspects of salmonellosis. We have developed a new model of Salmonella-induced fibrosis during chronic infection. We also studied the localization of Salmonella in the epithelium of the gallbladder, a process essential for its transport and release into the bile, which are associated with the spread of typhoid fever. We also examined the effects of Salmonella on the microbiota, and how it contributes to intestinal colonization and gastroenteritis. Various aspects of these interactions are discussed in the light of their contribution to salmonellosis.