Résumé
In this lecture, I will discuss recent work showing the effects of advancing age on neural stem cells. For example, his group had provided the first description of a diffusion barrier in the endplasmic reticulum (ER) in mammalian cells that appears to be involved in the asymmetric segregation of cellular age. Furthermore, he will present novel approaches that aim to directly visualize biological age of individual cells in complex tissues that may hold the potential to understand how aging, a highly heterogenous process among individuals but even within tissues, occurs in the mammalian brain.
