Amphithéâtre Guillaume Budé, Site Marcelin Berthelot
En libre accès, dans la limite des places disponibles
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Résumé

Histone modifications can regulate many chromatin-related processes such as transcription, replication and DNA-repair, they can demarcate the genomic position of regulatory elements such as enhancers and may be involved in disease processes if misregulated. Despite a vast body of (mainly correlative) data arguing in favor of a central role of histone modifications for chromatin-dependent process (e.g. activation or repression of transcription), it is currently not clear to what extent histone modifications indeed functionally contribute (e.g. have a causative function) to the processes they are associated with. Our data demonstrates now a functional role of histone modifications in transcription and adds a new interesting twist to the debate on the functionality and causality of PTMs for the regulation of chromatin fonctions.

Intervenant(s)

Robert Schneider

Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia