Abstract
In this fifth lecture, we look at the origin, manufacture and utility of liver organoids produced either from hepatocytes or from cholangiocytes (biliary epithelium). We study their potential importance in liver regeneration for therapeutic purposes. In the second part of this lecture, we begin to address the manufacture of mammalian embryos in vitro by studying " blastoids ", i.e. biological objects resembling early embryos at the pre-implantation stage :
- liver organoids, hepatocytes, cholangiocytes ;
- liver regeneration ;
- cell origins ;
- liver tumoroids ;
- human liver organoids derived from iPS cells ;
- aLGS patient liver organoids.
